{"entity":{"type":"insider","cik":"0001321261","url":"/insider/0001321261","json_url":"/insider/0001321261.json","name":"Wedel Mark K","name_source":"as-filed","also_issuer":false,"cross_url":null},"coverage_statement":{"n_transactions":5,"n_filings":5,"first":"2007-04-27","last":"2007-07-10","span_basis":"filed_date"},"name_variants":[{"name":"Wedel Mark K","source":"filing","n_filings":5,"first_seen":"2007-04-27","last_seen":"2007-07-10"}],"transactions":[{"id":6944919,"accession":"0000874015-07-000053","txn_seq":3,"anchor":"line-3","filing_url":"/filing/0000874015-07-000053","line_url":"/filing/0000874015-07-000053#line-3","is_derivative":false,"issuer_cik":"0000874015","issuer_name":"ISIS PHARMACEUTICALS INC","issuer_ticker":"ISIS","issuer_name_source":null,"issuer_url":"/issuer/0000874015","owner_cik":"0001321261","owner_name":"Wedel Mark K","owner_display_name":"Wedel Mark K","owner_url":"/insider/0001321261","role":"Officer (VP & Chief Medical Officer)","role_mark":"O","role_mark_label":"Officer (VP & Chief Medical Officer)","role_mark_generic":"Officer","n_reporting_owners":null,"other_reporting_owners":null,"officer_title":"VP & Chief Medical Officer","security_title":"Common Stock","transaction_code":"S","transaction_label":"Open-market sale","open_market":true,"acquired_disposed":"D","direction_word":"disposed","shares":5200.0,"shares_display":"5,200","price_per_share":10.1204,"price_display":"10.12","price_state":"stated","total_value":52626.08,"total_display":"52,626.08","total_whole":"52,626","shares_owned_after":6603.0,"shares_owned_after_display":"6,603","ownership_form":"D","is_10b5_1":null,"transaction_date":"2007-07-06","filed_date":"2007-07-10","scope":"insider"},{"id":7414622,"accession":"0000874015-07-000049","txn_seq":2,"anchor":"line-2","filing_url":"/filing/0000874015-07-000049","line_url":"/filing/0000874015-07-000049#line-2","is_derivative":false,"issuer_cik":"0000874015","issuer_name":"ISIS PHARMACEUTICALS INC","issuer_ticker":"ISIS","issuer_name_source":null,"issuer_url":"/issuer/0000874015","owner_cik":"0001321261","owner_name":"Wedel Mark K","owner_display_name":"Wedel Mark K","owner_url":"/insider/0001321261","role":"Officer (VP & Chief Medical Officer)","role_mark":"O","role_mark_label":"Officer (VP & Chief Medical Officer)","role_mark_generic":"Officer","n_reporting_owners":null,"other_reporting_owners":null,"officer_title":"VP & Chief Medical Officer","security_title":"Common Stock","transaction_code":"S","transaction_label":"Open-market sale","open_market":true,"acquired_disposed":"D","direction_word":"disposed","shares":902.0,"shares_display":"902","price_per_share":9.7029,"price_display":"9.70","price_state":"stated","total_value":8752.0158,"total_display":"8,752.02","total_whole":"8,752","shares_owned_after":6603.0,"shares_owned_after_display":"6,603","ownership_form":"D","is_10b5_1":null,"transaction_date":"2007-07-02","filed_date":"2007-07-03","scope":"insider"},{"id":6944911,"accession":"0000874015-07-000027","txn_seq":2,"anchor":"line-2","filing_url":"/filing/0000874015-07-000027","line_url":"/filing/0000874015-07-000027#line-2","is_derivative":false,"issuer_cik":"0000874015","issuer_name":"ISIS PHARMACEUTICALS INC","issuer_ticker":"ISIS","issuer_name_source":null,"issuer_url":"/issuer/0000874015","owner_cik":"0001321261","owner_name":"Wedel Mark K","owner_display_name":"Wedel Mark K","owner_url":"/insider/0001321261","role":"Officer (VP & Chief Medical Officer)","role_mark":"O","role_mark_label":"Officer (VP & Chief Medical Officer)","role_mark_generic":"Officer","n_reporting_owners":null,"other_reporting_owners":null,"officer_title":"VP & Chief Medical Officer","security_title":"Common Stock","transaction_code":"S","transaction_label":"Open-market sale","open_market":true,"acquired_disposed":"D","direction_word":"disposed","shares":2800.0,"shares_display":"2,800","price_per_share":10.364,"price_display":"10.36","price_state":"stated","total_value":29019.2,"total_display":"29,019.20","total_whole":"29,019","shares_owned_after":6603.0,"shares_owned_after_display":"6,603","ownership_form":"D","is_10b5_1":null,"transaction_date":"2007-05-09","filed_date":"2007-05-11","scope":"insider"},{"id":7167418,"accession":"0000874015-07-000026","txn_seq":2,"anchor":"line-2","filing_url":"/filing/0000874015-07-000026","line_url":"/filing/0000874015-07-000026#line-2","is_derivative":false,"issuer_cik":"0000874015","issuer_name":"ISIS PHARMACEUTICALS INC","issuer_ticker":"ISIS","issuer_name_source":null,"issuer_url":"/issuer/0000874015","owner_cik":"0001321261","owner_name":"Wedel Mark K","owner_display_name":"Wedel Mark K","owner_url":"/insider/0001321261","role":"Officer (VP & Chief Medical Officer)","role_mark":"O","role_mark_label":"Officer (VP & Chief Medical Officer)","role_mark_generic":"Officer","n_reporting_owners":null,"other_reporting_owners":null,"officer_title":"VP & Chief Medical Officer","security_title":"Common Stock","transaction_code":"S","transaction_label":"Open-market sale","open_market":true,"acquired_disposed":"D","direction_word":"disposed","shares":2000.0,"shares_display":"2,000","price_per_share":10.25,"price_display":"10.25","price_state":"stated","total_value":20500.0,"total_display":"20,500.00","total_whole":"20,500","shares_owned_after":6603.0,"shares_owned_after_display":"6,603","ownership_form":"D","is_10b5_1":null,"transaction_date":"2007-05-02","filed_date":"2007-05-04","scope":"insider"},{"id":7631355,"accession":"0000874015-07-000024","txn_seq":3,"anchor":"line-3","filing_url":"/filing/0000874015-07-000024","line_url":"/filing/0000874015-07-000024#line-3","is_derivative":false,"issuer_cik":"0000874015","issuer_name":"ISIS PHARMACEUTICALS INC","issuer_ticker":"ISIS","issuer_name_source":null,"issuer_url":"/issuer/0000874015","owner_cik":"0001321261","owner_name":"Wedel Mark K","owner_display_name":"Wedel Mark K","owner_url":"/insider/0001321261","role":"Officer (VP & Chief Medical Officer)","role_mark":"O","role_mark_label":"Officer (VP & Chief Medical Officer)","role_mark_generic":"Officer","n_reporting_owners":null,"other_reporting_owners":null,"officer_title":"VP & Chief Medical Officer","security_title":"Common Stock","transaction_code":"S","transaction_label":"Open-market sale","open_market":true,"acquired_disposed":"D","direction_word":"disposed","shares":13711.0,"shares_display":"13,711","price_per_share":10.11,"price_display":"10.11","price_state":"stated","total_value":138618.21,"total_display":"138,618.21","total_whole":"138,618","shares_owned_after":6603.0,"shares_owned_after_display":"6,603","ownership_form":"D","is_10b5_1":null,"transaction_date":"2007-04-25","filed_date":"2007-04-27","scope":"insider"}],"collapsed":true,"next_cursor":null,"ledger_fault":false,"count":{"value":5,"kind":"exact"},"open_market_only":false,"composition":{"kind":"exact","rows":[{"code":"P","label":"Open-market purchase","n":0,"open_market":true},{"code":"S","label":"Open-market sale","n":5,"open_market":true},{"code":"M","label":"Option exercise","n":0,"open_market":false},{"code":"A","label":"Grant or award","n":0,"open_market":false},{"code":"F","label":"Tax withholding","n":0,"open_market":false},{"code":"D","label":"Disposition to the issuer","n":0,"open_market":false},{"code":"X","label":"In-the-money option exercise","n":0,"open_market":false}],"total":5},"affiliations":[{"type":"issuer","type_label":"ISSUER","cik":"0000874015","name":"ISIS PHARMACEUTICALS INC","url":"/issuer/0000874015","role":"Officer (VP & Chief Medical Officer)","n_filings":5,"first_seen":"2007-04-27","last_seen":"2007-07-10"}],"order_statement":"Newest transaction date first, id breaking the tie.","canonical_url":"https://ebomi.com/insider/0001321261","retrieved_at":"2026-08-27T06:32:47+00:00","coverage":{"filings":1506293,"transactions":4290787,"issuers":28597,"insiders":152303,"first_filed_date":"2003-06-30","last_filed_date":"2026-08-26","last_ingest":"2026-08-27T05:24:39.644631+00:00","counts_are":{"filings":"estimate","transactions":"estimate","issuers":"estimate","insiders":"estimate"},"source":"SEC EDGAR Form 4 filings, parsed by ebomi","fault":false},"license":{"underlying_records":"US SEC filings are public records of the United States government and are not subject to copyright. The transactional facts in them are not ours to license.","this_presentation":"The parsing, normalisation, curation, and presentation are ebomi's own work.","grant":"undecided","grant_note":"The open licence for ebomi's own layer is an open owner decision (SPEC-20260731T1159Z open question 3: CC BY 4.0 or CC0 with a citation request). Until it is taken, no grant is asserted here.","citation_request":"Balogh, A. Insider trading. Scientific Data 10, 237 (2023)","url":"https://ebomi.com/license"},"fair_use":{"policy":"These JSON endpoints are open and unauthenticated. Please read them at a human pace, identify your client in the User-Agent header, and use the published dataset for bulk work rather than crawling page by page.","bulk_alternative":"doi:10.1038/s41597-023-02147-6"}}